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Spicy Southern Chicken Spaghetti Casserole, the best ever comfort food, is shown as a featured image.

Spicy Southern Chicken Spaghetti Casserole

This Spicy Southern Chicken Spaghetti Casserole is the ultimate comfort food, blending creamy, cheesy goodness with a touch of heat. Perfect for weeknight dinners or potlucks, this casserole is easy to make and sure to impress with its layers of flavor.
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Prep Time 20 minutes
Cook Time 30 minutes
Total Time 50 minutes
Servings: 6
Course: Main Course
Cuisine: Southern
Calories: 450
Ingredients Equipment Method Notes

Ingredients
  

  • 1 pound spaghetti
  • 2 tablespoons butter
  • 1/2 cup chopped onion
  • 1/4 cup chopped green bell pepper
  • 2 cloves garlic, minced
  • 2 cups cooked chicken, shredded
  • 8 ounces cream cheese, softened
  • 1 cup shredded cheddar cheese
  • 1/2 cup shredded Monterey Jack cheese
  • 1 teaspoon chili powder
  • 1/2 teaspoon cumin
  • 1/4 teaspoon cayenne pepper optional
  • Salt and pepper to taste
  • Cooking spray or butter for greasing the dish

Equipment

  • 9x13 inch baking dish
  • Large pot
  • Colander
  • Large Skillet
  • Large bowl
  • Measuring cups and spoons
  • Knife
  • Cutting board

Method
 

  1. Preheat your oven to 350°F (175°C). Grease a 9x13 inch baking dish.
  2. Cook the spaghetti according to package directions until al dente. Drain well and set aside.
  3. While the spaghetti is cooking, melt the butter in a large skillet over medium heat.
  4. Add the onion and green bell pepper and cook until softened, about 5-7 minutes.
  5. Add the minced garlic and cook for another minute, until fragrant. Be careful not to burn the garlic.
  6. In a large bowl, combine the cooked spaghetti, shredded chicken, cream of chicken soup, Rotel, softened cream cheese, cheddar cheese, Monterey Jack cheese, sautéed vegetables, chili powder, cumin, and cayenne pepper (if using).
  7. Season with salt and pepper to taste. Mix everything together until well combined.
  8. Pour the mixture into the prepared baking dish. Spread it out evenly.
  9. Bake for 25-30 minutes, or until heated through and bubbly. The top should be lightly golden brown.
  10. Let the casserole cool for a few minutes before serving.

Notes

For a richer flavor, use rotisserie chicken. To customize the spice level, choose mild, medium, or hot Rotel. This casserole can be assembled ahead of time and refrigerated for up to 24 hours before baking. If freezing, wrap tightly in plastic wrap and foil, and thaw overnight in the refrigerator before baking. For a crunchy topping, sprinkle crushed crackers or breadcrumbs on top before baking. Store leftovers in an airtight container in the refrigerator for up to 3 days.