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Chicken Spaghetti Casserole featured image showcasing the creamy, cheesy baked pasta dish.

Perfect Chicken Spaghetti Casserole

This Chicken Spaghetti Casserole is the ultimate comfort food, blending creamy, cheesy goodness with tender chicken and perfectly cooked spaghetti. It's an easy-to-make dish that's perfect for family gatherings, potlucks, or a cozy weeknight dinner, promising a delightful and satisfying experience.
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Prep Time 25 minutes
Cook Time 45 minutes
Total Time 1 hour 10 minutes
Servings: 6
Course: Main Course
Cuisine: American
Calories: 550
Ingredients Equipment Method Notes

Ingredients
  

  • 1.5 lbs boneless, skinless chicken breasts
  • 1 tbsp olive oil
  • 1 tsp salt
  • 1/2 tsp black pepper
  • 1/2 tsp garlic powder
  • 1 lb spaghetti
  • 8 oz cream cheese, softened
  • 1/2 cup milk
  • 1/2 cup shredded cheddar cheese, plus more for topping
  • 1/4 cup chopped onion
  • 1/4 cup chopped green bell pepper
  • 1 tsp Worcestershire sauce
  • Salt to taste
  • Pepper to taste

Equipment

  • 9x13 inch baking dish
  • Large pot
  • Colander
  • Large bowl
  • Mixing Spoon
  • Measuring cups and spoons
  • Oven
  • Meat thermometer (optional)

Method
 

  1. Preheat oven to 350°F (175°C).
  2. Rub chicken breasts with olive oil, salt, pepper, and garlic powder.
  3. Bake for 25-30 minutes, or until cooked through. Use a meat thermometer to ensure internal temperature reaches 165°F (74°C).
  4. Let cool slightly, then shred or dice the chicken. Set aside.
  5. Cook spaghetti according to package directions. Drain well.
  6. In a large bowl, combine softened cream cheese, cream of mushroom soup, cream of chicken soup, Rotel, milk, cheddar cheese, onion, green bell pepper, and Worcestershire sauce.
  7. Mix until smooth and well combined. Season with salt and pepper to taste.
  8. Add the cooked spaghetti and shredded chicken to the creamy sauce.
  9. Stir until everything is evenly coated.
  10. Pour the mixture into a greased 9x13 inch baking dish.
  11. Sprinkle with additional cheddar cheese on top.
  12. Bake for 20-25 minutes, or until bubbly and the cheese is melted and lightly browned.
  13. Let stand for a few minutes before serving.

Notes

Don't overcook the chicken to avoid dryness. Ensure cream cheese is fully softened for a smooth sauce. Adjust spice levels to your preference by adding cayenne pepper or hot sauce. Customize with vegetables like mushrooms, corn, or peas. Prepare ahead by assembling up to the baking step and refrigerate for up to 24 hours. Store leftovers in the refrigerator for 3-4 days or freeze for longer storage. For a Tex-Mex variation, add taco seasoning, black beans, and corn, topping with crushed tortilla chips. For a Creamy Pesto version, stir in pesto and sun-dried tomatoes. For a Spicy Cajun kick, add Cajun seasoning and Cajun-style cream of mushroom soup. For a Cheesy Broccoli boost, add steamed broccoli florets or use cream of broccoli soup.